Transcriptional patterns of sexual dimorphism and in host developmental programs in the model parasitic nematode Heligmosomoides bakeri, Parasites & Vectors
Por um escritor misterioso
Last updated 24 março 2025

Background Heligmosomoides bakeri (often mistaken for Heligmosomoides polygyrus) is a promising model for parasitic nematodes with the key advantage of being amenable to study and manipulation within a controlled laboratory environment. While draft genome sequences are available for this worm, which allow for comparative genomic analyses between nematodes, there is a notable lack of information on its gene expression. Methods We generated biologically replicated RNA-seq datasets from samples taken throughout the parasitic life of H. bakeri. RNA from tissue-dwelling and lumen-dwelling worms, collected under a dissection microscope, was sequenced on an Illumina platform. Results We find extensive transcriptional sexual dimorphism throughout the fourth larval and adult stages of this parasite and identify alternative splicing, glycosylation, and ubiquitination as particularly important processes for establishing and/or maintaining sex-specific gene expression in this species. We find sex-linked differences in transcription related to aging and oxidative and osmotic stress responses. We observe a starvation-like signature among transcripts whose expression is consistently upregulated in males, which may reflect a higher energy expenditure by male worms. We detect evidence of increased importance for anaerobic respiration among the adult worms, which coincides with the parasite’s migration into the physiologically hypoxic environment of the intestinal lumen. Furthermore, we hypothesize that oxygen concentration may be an important driver of the worms encysting in the intestinal mucosa as larvae, which not only fully exposes the worms to their host’s immune system but also shapes many of the interactions between the host and parasite. We find stage- and sex-specific variation in the expression of immunomodulatory genes and in anthelmintic targets. Conclusions We examine how different the male and female worms are at the molecular level and describe major developmental events that occur in the worm, which extend our understanding of the interactions between this parasite and its host. In addition to generating new hypotheses for follow-up experiments into the worm’s behavior, physiology, and metabolism, our datasets enable future more in-depth comparisons between nematodes to better define the utility of H. bakeri as a model for parasitic nematodes in general. Graphical Abstract

Frontiers Immunomodulation and Immune Escape Strategies of

Transcriptional patterns of sexual dimorphism and in host

Frontiers Reciprocal Interactions between Nematodes and Their

PDF) Estimation of C. elegans cell- and tissue volumes

The production of excretory-secretory molecules from

TGF-β mimic proteins form an extended gene family in the murine

HpARI Protein Secreted by a Helminth Parasite Suppresses

Whipworm and roundworm infections

Diversity, Free Full-Text

Dictyocaulus viviparus genome, variome and transcriptome elucidate

Schistosome and intestinal helminth modulation of macrophage

Biomolecules, Free Full-Text

Dictyocaulus viviparus genome, variome and transcriptome

Frontiers Reciprocal Interactions between Nematodes and Their

The genome and transcriptome of the zoonotic hookworm Ancylostoma
Recomendado para você
-
Life Cycle of a Hamster by Johanna Iline24 março 2025
-
Golden hamster - Wikipedia24 março 2025
-
The hamster life cycle: Stages from birth to old age24 março 2025
-
Syrian hamster breeding - Wikipedia24 março 2025
-
Frontiers Syrian hamster as an ideal animal model for evaluation of cancer immunotherapy24 março 2025
-
All About the Hamster: The Pouch-Cheeked Rodent - Gage Beasley Wildlife24 março 2025
-
How Long Do Gerbils Live? Gerbil Lifespan as Pets and in the Wild - LittleGrabbies24 março 2025
-
Rat Lifecycle — APC Management24 março 2025
-
Laboratory maintenance of the bacterial endosymbiont, Neorickettsia sp., through the life cycle of a digenean, Plagiorchis elegans - ScienceDirect24 março 2025
-
VolksRose Wooden Hamster Playground Platform, Hamster24 março 2025
você pode gostar
-
Pokemon Go - Level 23 - Escolhendo a evolução da Eevee24 março 2025
-
Os melhores aplicativos grátis para instalar no seu novo notebook24 março 2025
-
Coloriage kawaii Unicorn coloring pages, Candy coloring pages24 março 2025
-
Sonic Frontiers: Convergence - Full comic - Tails' Channel24 março 2025
-
Em cada um dosproblemas de 7a12:(a) Esboce o gráfico da funç24 março 2025
-
Painel Lancheira - Meia Tigela - Borboleta24 março 2025
-
2021 Nashville Holiday Gift Guide24 março 2025
-
Overlord Male Reader Insert - Part 3: The Slain Theocracy Attacks - Wattpad24 março 2025
-
RED VELVET 3rd mini album Russian Roulette Official Photocard Irene Seulgi KPOP24 março 2025
-
Liga Revelação Sub-23 Tabela, Estatísticas e Resultados - Portugal24 março 2025