GPC2-CAR T cells tuned for low antigen density mediate potent
Por um escritor misterioso
Last updated 08 abril 2025

Pediatric cancers often mimic fetal tissues and express proteins normally silenced postnatally that could serve as immune targets. We developed T cell…

GPC2-CAR T cells tuned for low antigen density mediate potent activity against neuroblastoma without toxicity - ScienceDirect

CAR T cells targeting tumor-associated exons of glypican 2 regress neuroblastoma in mice - ScienceDirect

CD276-CAR T cells and Dual-CAR T cells targeting CD276/FGFR4 promote rhabdomyosarcoma clearance in orthotopic mouse models, Journal of Experimental & Clinical Cancer Research

Full article: B7-H3-targeted CAR-T cell therapy for solid tumors

Preclinical development of a chimeric antigen receptor T cell therapy targeting FGFR4 in rhabdomyosarcoma - ScienceDirect

Overcoming on-target, off-tumour toxicity of CAR T cell therapy for solid tumours

Recent advances and discoveries in the mechanisms and functions of CAR T cells

GPC2-CAR T cells tuned for low antigen density mediate potent activity against neuroblastoma without toxicity - ScienceDirect

Preclinical development of a chimeric antigen receptor T cell therapy targeting FGFR4 in rhabdomyosarcoma - ScienceDirect

Overcoming on-target, off-tumour toxicity of CAR T cell therapy for solid tumours

CAR-T Therapies in Solid Tumors: Opportunities and Challenges

Cancers, Free Full-Text

PDF) Preclinical optimization of a GPC2-targeting CAR T-cell therapy for neuroblastoma

Targeted delivery of interferon-gamma by synNotch T cells sensitizes neuroblastoma cells to T cell-mediated killing
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