GPC2-CAR T cells tuned for low antigen density mediate potent

Pediatric cancers often mimic fetal tissues and express proteins normally silenced postnatally that could serve as immune targets. We developed T cell…

GPC2-CAR T cells tuned for low antigen density mediate potent activity against neuroblastoma without toxicity - ScienceDirect

CAR T cells targeting tumor-associated exons of glypican 2 regress neuroblastoma in mice - ScienceDirect

CD276-CAR T cells and Dual-CAR T cells targeting CD276/FGFR4 promote rhabdomyosarcoma clearance in orthotopic mouse models, Journal of Experimental & Clinical Cancer Research

Full article: B7-H3-targeted CAR-T cell therapy for solid tumors

Preclinical development of a chimeric antigen receptor T cell therapy targeting FGFR4 in rhabdomyosarcoma - ScienceDirect

Overcoming on-target, off-tumour toxicity of CAR T cell therapy for solid tumours

Recent advances and discoveries in the mechanisms and functions of CAR T cells

GPC2-CAR T cells tuned for low antigen density mediate potent activity against neuroblastoma without toxicity - ScienceDirect

Preclinical development of a chimeric antigen receptor T cell therapy targeting FGFR4 in rhabdomyosarcoma - ScienceDirect

Overcoming on-target, off-tumour toxicity of CAR T cell therapy for solid tumours

CAR-T Therapies in Solid Tumors: Opportunities and Challenges

Cancers, Free Full-Text

PDF) Preclinical optimization of a GPC2-targeting CAR T-cell therapy for neuroblastoma

Targeted delivery of interferon-gamma by synNotch T cells sensitizes neuroblastoma cells to T cell-mediated killing