Is This a JoJo Reference?: The Rise of Anime's Ultimate Meme

The rhetorical question of "Is this a JoJo reference?" has become omnipresent on the Internet. Confused by it? Here

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Metal Gear Solid is a Jojo's Bizarre Adventure reference???

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Episode 1, Katakuri is a Jojo's reference #tamirsverse #anime #onepi, katakuri

That's a fucking JoJo reference and not the first one either : r/goodanimemes

Is Jojo's Bizarre Adventure the only anime/manga with an artstyle that's 100% realistic hence why it's so unique and recognizable or is there some other diamonds in the field of gold?