Temozolomide (NSC 362856), DNA Alkylator

Temozolomide (NSC 362856) is an oral active DNA alkylating agent that crosses the blood-brain barrier. Temozolomide is also a proautophagic and proapoptotic agent. Temozolomide is effective against tumor cells that are characterized by low levels of O6-alkylguanine DNA alkyltransferase (OGAT) and a functional mismatch repair system. Temozolomide has antitumor and antiangiogenic effects. - Mechanism of Action & Protocol.

Novel strategies of Raman imaging for monitoring the therapeutic benefit of temozolomide in glioblastoma - ScienceDirect

Biomedicines, Free Full-Text

Biomedicines, Free Full-Text

Temozolomide CAS:85622-93-1 Probechem Biochemicals

Temozolomide (NSC 362856), DNA Alkylator

Temozolomide: -- Mechanism of Action: ----Alkylate/methylate DNA, that

Crosstalk between repair pathways elicits double-strand breaks in alkylated DNA and implications for the action of temozolomide

Fig 1., Temozolomide (Temodar)

Improving temozolomide biopharmaceutical properties in glioblastoma multiforme (GBM) treatment using GBM-targeting nanocarriers - ScienceDirect