Molecular mechanism(s) of neurodegeneration in Niemann-Pick type C disease - Ruđer Bošković Institute

The goal of this project is to elucidate the molecular mechanism(s) of neurodegeneration in Niemann-Pick type C disease (NPC). We will investigate the role of protease BACE1, the key Alzheimer's disease (AD) enzyme, in the pathogenesis of NPC disease. We hope that our findings will elucidate BACE1 as a novel target for treating/ameliorating NPC disease.

Promoting the clearance of neurotoxic proteins in

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Niemann‐Pick type C disease: molecular mechanisms and potential

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Lysosomal dysfunction as a common mechanism of neurodegenerative

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From genes to hope

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Molecular mechanism(s) of cholesterol-effect on APP and BACE1

Solving neurodegeneration: common mechanisms and strategies for

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mRNA Treatment Rescues Niemann–Pick Disease Type C1 in Patient

Common mechanisms involved in neurodegeneration.

Marko KOSICEK, PhD, Ruđer Bošković Institute, Zagreb

Niemann-Pick Disease Concise Medical Knowledge