Local Protein Synthesis and Spine Morphogenesis: Fragile X Syndrome and Beyond

Behavioral experiences can modulate neural networks through changes in synaptic morphology and number. In contrast, abnormal morphogenesis of dendritic spines is associated with cognitive impairment, as in Fragile X syndrome. Dendritic or synaptic protein synthesis could provide the specificity and speed necessary for spine morphogenesis. Here, we highlight locally translated proteins shown to affect synaptic morphology (e.g., Fragile X mental retardation protein).

Synaptic Activity Controls Dendritic Spine Morphology by

Dissociation of functional and structural plasticity of dendritic spines

Brain Sciences, Free Full-Text

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Pten heterozygosity restores neuronal morphology in fragile X

Reciprocal regulation of spontaneous synaptic vesicle fusion by

Frontiers The Coordination of Local Translation, Membranous

Frontiers Homeostatic Roles of the Proteostasis Network in Dendrites

Fragile X mental retardation protein controls synaptic vesicle

IJMS, Free Full-Text

Pten heterozygosity restores neuronal morphology in fragile X

Frontiers Fragile X Mental Retardation Protein Regulates

Frontiers Local mRNA translation and cytoskeletal reorganization