Homobivalent Dopamine D2 Receptor Ligands Modulate the Dynamic Equilibrium of D2 Monomers and Homo- and Heterodimers

Biphasic competition-binding curves indicate a bivalent binding mode.

Functional consequences of GPCR heterodimerization. (A). As in the case

Design of a True Bivalent Ligand with Picomolar Binding Affinity for a G Protein-Coupled Receptor Homodimer

Alteration of D2R-DAT protein-protein interaction in AISS rats.

IJMS, Free Full-Text

Effect of CLZ and HAL treatment on specific binding of [ 3

PDF) The Fourth Transmembrane Segment Forms the Interface of the Dopamine D2 Receptor Homodimer

The dopamine D2 receptor dimer and its interaction with homobivalent antagonists: homology modeling, docking and molecular dynamics

PDF) Heterodimerization of Mu Opioid Receptor Protomer with Dopamine D2 Receptor Modulates Agonist-Induced Internalization of Mu Opioid Receptor

Schematic representation of wild type dopamine D 2 and D 3 receptors

Homobivalent Dopamine D2 Receptor Ligands Modulate the Dynamic Equilibrium of D2 Monomers and Homo- and Heterodimers

Schematic model, showing dynamic equilibrium of the class-A GPCR

Schematic model, showing dynamic equilibrium of the class-A GPCR