Life, Free Full-Text
Por um escritor misterioso
Last updated 16 março 2025

While fetal growth is dependent on many factors, optimal placental function is a prerequisite for a normal pregnancy outcome. The majority of fetal growth-restricted (FGR) pregnancies result from placental insufficiency (PI). The insulin-like growth factors (IGF1 and IGF2) stimulate fetal growth and placental development and function. Previously, we demonstrated that in vivo RNA interference (RNAi) of the placental hormone, chorionic somatomammotropin (CSH), resulted in two phenotypes. One phenotype exhibits significant placental and fetal growth restriction (PI-FGR), impaired placental nutrient transport, and significant reductions in umbilical insulin and IGF1. The other phenotype does not exhibit statistically significant changes in placental or fetal growth (non-FGR). It was our objective to further characterize these two phenotypes by determining the impact of CSH RNAi on the placental (maternal caruncle and fetal cotyledon) expression of the IGF axis. The trophectoderm of hatched blastocysts (9 days of gestation, dGA) were infected with a lentivirus expressing either a non-targeting sequence (NTS RNAi) control or CSH-specific shRNA (CSH RNAi) prior to embryo transfer into synchronized recipient ewes. At ≈125 dGA, pregnancies were fitted with vascular catheters to undergo steady-state metabolic studies. Nutrient uptakes were determined, and tissues were harvested at necropsy. In both CSH RNAi non-FGR and PI-FGR pregnancies, uterine blood flow was significantly reduced (p ≤ 0.05), while umbilical blood flow (p ≤ 0.01), both uterine and umbilical glucose and oxygen uptakes (p ≤ 0.05), and umbilical concentrations of insulin and IGF1 (p ≤ 0.05) were reduced in CSH RNAi PI-FGR pregnancies. Fetal cotyledon IGF1 mRNA concentration was reduced (p ≤ 0.05) in CSH RNAi PI-FGR pregnancies, whereas neither IGF1 nor IGF2 mRNA concentrations were impacted in the maternal caruncles, and either placental tissue in the non-FGR pregnancies. Fetal cotyledon IGF1R and IGF2R mRNA concentrations were not impacted for either phenotype, yet IGF2R was increased (p ≤ 0.01) in the maternal caruncles of CSH RNAi PI-FGR pregnancies. For the IGF binding proteins (IGFBP1, IGFBP2, IGFBP3), only IGFBP2 mRNA concentrations were impacted, with elevated IGFBP2 mRNA in both the fetal cotyledon (p ≤ 0.01) and maternal caruncle (p = 0.08) of CSH RNAi non-FGR pregnancies. These data support the importance of IGF1 in placental growth and function but may also implicate IGFBP2 in salvaging placental growth in non-FGR pregnancies.
A little message to encourage you to build a beautiful life. From the book: A Gentle Touch of Life❤️ You can read it on kindle for free…

Cancer Drug Resistance is Now Indexed in PubMed Central

People Who Use Drugs Talk about Hep C — Hep Free Hawaii

Ann Voskamp Quote: “We only enter into the full life if our faith gives thanks. Because how else do we accept His free gift of salvation if ”

Life Is Full Of Possibilities Inspirational Quote In English, Hand Drawn Text Illustration, Decorative Design Words In Curly Fonts. Great Design For Greeting Card Or A Print. Isolated On White Royalty Free

Live Life In Full Bloom, Inspirational Wood Sign
4th Grade Life Science Reading Comprehension FREE - Official app in the Microsoft Store

FREE Stay Active & Independent for Life Fitness Class - One Senior Place

Live Life Full Bloom Stock Illustrations – 73 Live Life Full Bloom Stock Illustrations, Vectors & Clipart - Dreamstime
Recomendado para você
-
Rapid visco analysis (RVA) profiles of starch suspensions [10.0% w16 março 2025
-
Números 14:28 RVA - Diles: Vivo yo, dice Jehová, que según habéis16 março 2025
-
Grupo RVA dá início ao Pinheiro Solidário - Portal RVA16 março 2025
-
RVI FM, Rádio RVI FM 98.7 FM, Duque de Caxias, Brazil16 março 2025
-
HANUMAN,BHAGWA,HINDU,BHAGWAN,GOD VIVO V23 5G16 março 2025
-
No Te Quiero Perder - En Vivo – música e letra de Irving Mejía y16 março 2025
-
RVA Smash 104: Milesisbae (Hero) vs Okamifire (Banjo & Kazooie), Winners Semis, 28 Entrants16 março 2025
-
Full article: Intestinal mucin-type O-glycans: the major players in the host-bacteria-rotavirus interactions16 março 2025
-
Twitch16 março 2025
-
Meia Infantil Reserva em Promoção16 março 2025
você pode gostar
-
Highlight 60M Rumble + Cyborg V4 + God Human + CDK (Blox Fruits Bounty Hunting) Road to 30M Honor16 março 2025
-
Wave Cake Bolos de aniversário azuis, Bolos azuis, Bolo de aniversario adulto16 março 2025
-
My dream is that Elfen Lied gets more figures some day, what is your dream figure? : r/AnimeFigures16 março 2025
-
Big Shot Boxing 2.7 Free Download16 março 2025
-
Dragon Fruit Pink16 março 2025
-
Devil May Cry PlayStation 2 Box Art Cover by pressure666616 março 2025
-
Pop Race Facebook16 março 2025
-
Perguntas Frequentes sobre as edições de Call of Duty: Modern16 março 2025
-
One Piece Ikinuke! Haha Bellemere to Nami no Kizuna! (TV Episode16 março 2025
-
My 600-lb Life': Dr. Now On Why His Job Is a 'Daily Challenge16 março 2025