JoF, Free Full-Text

Paracoccidioidomycosis (PCM) is a systemic mycosis caused by fungi of the genus Paracoccidioides and the different clinical forms of the disease are associated with the host immune responses. Quantitative trait loci mapping analysis was performed to assess genetic variants associated with mononuclear-cells-derived cytokines induced by P. brasiliensis on 158 individuals. We identified the rs11053595 SNP, which is present in the CLEC7A gene (encodes the Dectin-1 receptor) and the rs62290169 SNP located in the PROM1 gene (encodes CD133) associated with the production of IL-1β and IL-22, respectively. Functionally, the blockade of the dectin-1 receptor abolished the IL-1β production in P. brasiliensis-stimulated PBMCs. Moreover, the rs62290169-GG genotype was associated with higher frequency of CD38+ Th1 cells in PBMCs cultured with P. brasiliensis yeasts. Therefore, our research indicates that the CLEC7A and PROM1 genes are important for the cytokine response induced by P. brasiliensis and may influence the Paracoccidioidomycosis disease outcome.

Hoefler Text Font Free - Get Font Free

Full article: Original Abstracts from the 18th Annual Meeting of ISMPP

Solved Question 1 of 40 The acceleration of free full of a

Guided paragraph writing : a first course in English composition with structural practice : Jupp, T. C. (Thomas Cyprian) : Free Download, Borrow, and Streaming : Internet Archive

Full article: Incidence and Factors Related to Prolonged Postoperative Cognitive Decline (POCD) in Elderly Patients Following Surgery and Anaesthesia: A Systematic Review

S4 League Male Itc - Colaboratory

Farnood By Jaun Elia : Jaun Elia : Free Download, Borrow, and Streaming : Internet Archive

The HighWire archive consists of 7,100,000 articles and 3,500,000 free full- text articles that could be stor…

PDF] Long non-coding RNA XIST predicts worse prognosis in digestive system tumors: a systemic review and meta-analysis