IJMS, Free Full-Text
Por um escritor misterioso
Last updated 17 março 2025

Niemann–Pick type C (NPC) disease is an autosomal recessive storage disorder, characterized by abnormal sequestration of unesterified cholesterol in the late endo-lysosomal system of cells. Progressive neurological deterioration and the onset of symptoms, such as ataxia, seizures, cognitive decline, and severe dementia, are pathognomonic features of the disease. In addition, different pathological similarities, including degeneration of hippocampal and cortical neurons, hyperphosphorylated tau, and neurofibrillary tangle formation, have been identified between NPC disease and other neurodegenerative pathologies. However, the underlying pathophysiological mechanisms are not yet well understood, and even a real cure to counteract neurodegeneration has not been identified. Therefore, the combination of current pharmacological therapies, represented by miglustat and cyclodextrin, and non-pharmacological approaches, such as physical exercise and appropriate diet, could represent a strategy to improve the quality of life of NPC patients. Based on this evidence, in our review we focused on the neurodegenerative aspects of NPC disease, summarizing the current knowledge on the molecular and biochemical mechanisms responsible for cognitive impairment, and suggesting physical exercise and nutritional treatments as additional non-pharmacologic approaches to reduce the progression and neurodegenerative course of NPC disease.

Ijms Free Full Text Abnormalities In Alternative 25056

IJMS, Free Full-Text

IJMS Free Full Text A High Molecular Mass 26650

IJMS, Free Full-Text

Mpep Substantially Free - Colaboratory

IJMS, Free Full-Text

IJMS, Free Full-Text

IJMS, Free Full-Text

IJMS, Free Full-Text

Ijms Free Full Text Delayed Onset Of Age Dependent Changes In Ultrastructure Of Myocardial 116100

Pat Testing Labels Template Unique Ijms Free Full Text Genome Editing In Agriculture - Best Templates Ideas, Best Tem…
Recomendado para você
-
Niemann-Pick disease type C: Video & Anatomy17 março 2025
-
Niemann-Pick Type C « Niemann-Pick Children's Fund, Inc17 março 2025
-
Niemann-Pick Type C Disease Reveals a Link between Lysosomal Cholesterol and PtdIns(4,5)P2 That Regulates Neuronal Excitability - ScienceDirect17 março 2025
-
Niemann-Pick disease type C as a neurovisceral disease. Schematic17 março 2025
-
Revista de Pediatria SOPERJ17 março 2025
-
Síndrome de Niemann Pick Tipo C, enfermedad rara. Vértigo saludable17 março 2025
-
mvnpc3 MedLink Neurology17 março 2025
-
Niemann-Pick tipo C: entenda uma das doenças que causa demência infantil
— Site Oficial MEDPUC-Rio17 março 2025 -
Demência na infância: 'Meus três filhos receberam diagnóstico terminal' - BBC News Brasil17 março 2025
-
Niemann-Pick disease type C, Orphanet Journal of Rare Diseases17 março 2025
você pode gostar
-
TC Games17 março 2025
-
Cinema: 'Assassino Sem Rastro', 'A Hora do Desespero' e 'Até a Morte' entram em cartaz - Portal do Marcos Santos17 março 2025
-
Casas à venda no Cristo Rei em Pato Branco17 março 2025
-
Vestido Xadrez Vermelho Coleção de Natal17 março 2025
-
Papers, Please (TF2 version) by Grido555 on DeviantArt17 março 2025
-
Espero ter ajudado vcs ❤️#DiaDosPais #netflix17 março 2025
-
Taming io 🔥 Play online17 março 2025
-
CARE BABY SPONGEBOB, JOGOS BOB ESPONJA, SPONGEBOB GAMES, BABY CARE GAMES17 março 2025
-
Cartas de tarô preto com guia para iniciantes, adivinhação, alma, russo, português, 78 cartas, 12x7cm17 março 2025
-
EVERYBODY xxxx V3 ~ Original Soundtrack Relaxing Paripi Koumei - 「パリピ孔明」 - Ya Boy Kongming from xxxxv3 Watch Video17 março 2025