IJMS, Free Full-Text
Por um escritor misterioso
Last updated 16 março 2025

MHCII molecules, expressed by professional antigen-presenting cells (APCs) such as T cells and B cells, are hypothesized to play a key role in the response of cellular immunity to α-synuclein (α-syn). However, the role of cellular immunity in the neuroanatomic transmission of α-syn pre-formed fibrillar (PFF) seeds is undetermined. To illuminate whether cellular immunity influences the transmission of α-syn seeds from the periphery into the CNS, we injected preformed α-syn PFFs in the hindlimb of the Line M83 transgenic mouse model of synucleinopathy lacking MhcII. We showed that a complete deficiency in MhcII accelerated the appearance of seeded α-syn pathology and shortened the lifespan of the PFF-seeded M83 mice. To characterize whether B-cell and T-cell inherent MhcII function underlies this accelerated response to PFF seeding, we next injected α-syn PFFs in Rag1−/− mice which completely lacked these mature lymphocytes. There was no alteration in the lifespan or burden of endstage α-syn pathology in the PFF-seeded, Rag1-deficient M83+/− mice. Together, these results suggested that MhcII function on immune cells other than these classical APCs is potentially involved in the propagation of α-syn in this model of experimental synucleinopathy. We focused on microglia next, finding that while microglial burden was significantly upregulated in PFF-seeded, MhcII-deficient mice relative to controls, the microglial activation marker Cd68 was reduced in these mice, suggesting that these microglia were not responsive. Additional analysis of the CNS showed the early appearance of the neurotoxic astrocyte A1 signature and the induction of the Ifnγ-inducible anti-viral response mediated by MhcI in the MhcII-deficient, PFF-seeded mice. Overall, our data suggest that the loss of MhcII function leads to a dysfunctional response in non-classical APCs and that this response could potentially play a role in determining PFF-induced pathology. Collectively, our results identify the critical role of MhcII function in synucleinopathies induced by α-syn prion seeds.

IJMS, Free Full-Text

IJMS, Free Full-Text
IJMS Free Full-Text Research Advances In Mechanical, 52% OFF

IJMS, Free Full-Text

IJMS Free Full Text A High Molecular Mass 26650

IJMS, Free Full-Text
Ijms Free Full Text Neural And Hormonal Basis Of 49680

IJMS Free Full Text Cell Adhesion And Its Endocytic Regulation

IJMS, Free Full-Text
Recomendado para você
-
Le Mouvement - Pablo Bronstein16 março 2025
-
Gmail - Bronstein Mega Méier16 março 2025
-
Bronstein Medicina Diagnóstica - Méier - R. Dias da Cruz, 30816 março 2025
-
Mylene T. Truong MD Anderson Cancer Center16 março 2025
-
Chess: Magnus Carlsen serene while Fabiano Caruana faces hectic16 março 2025
-
Sharon Stone with her son Roan Joseph Bronstein on arrival GQ Men16 março 2025
-
27 German Woman Kidnapped In Kabul Stock Photos, High-Res Pictures16 março 2025
-
Bronstein Medicina Diagnóstica - Méier I (Megaunidade), R. Dias da16 março 2025
-
Para presidente do Cremerj, redes de laboratórios não acompanharam16 março 2025
-
Gmail - Confirmação de Agendamento - Bronstein Medicina16 março 2025
você pode gostar
-
Red Barrels Launches Early Access For The Outlast Trials - Red Barrels16 março 2025
-
Noblesse - Dublado - - Animes Online16 março 2025
-
Pokémon reveals Captain Pikachu, star of the new post-Ash Ketchum16 março 2025
-
Paredes pretas: saiba como aplicar a cor sem deixar o ambiente pesado16 março 2025
-
Demon Slayer: The Hinokami Chronicles: novo trailer do jogo foca16 março 2025
-
Download Handsome Anime Boy Zuko Fanart Wallpaper16 março 2025
-
The Legend of Zelda Ocarina of Time Gold Collector's Edition16 março 2025
-
IHOP opens sixth Milwaukee-area location, Taco John's newest shop nears debut: Quick Bites - Milwaukee Business Journal16 março 2025
-
Hotkey by Aldog16 março 2025
-
Chess Notes by Edward Winter16 março 2025