IJMS, Free Full-Text
Por um escritor misterioso
Last updated 28 março 2025

MHCII molecules, expressed by professional antigen-presenting cells (APCs) such as T cells and B cells, are hypothesized to play a key role in the response of cellular immunity to α-synuclein (α-syn). However, the role of cellular immunity in the neuroanatomic transmission of α-syn pre-formed fibrillar (PFF) seeds is undetermined. To illuminate whether cellular immunity influences the transmission of α-syn seeds from the periphery into the CNS, we injected preformed α-syn PFFs in the hindlimb of the Line M83 transgenic mouse model of synucleinopathy lacking MhcII. We showed that a complete deficiency in MhcII accelerated the appearance of seeded α-syn pathology and shortened the lifespan of the PFF-seeded M83 mice. To characterize whether B-cell and T-cell inherent MhcII function underlies this accelerated response to PFF seeding, we next injected α-syn PFFs in Rag1−/− mice which completely lacked these mature lymphocytes. There was no alteration in the lifespan or burden of endstage α-syn pathology in the PFF-seeded, Rag1-deficient M83+/− mice. Together, these results suggested that MhcII function on immune cells other than these classical APCs is potentially involved in the propagation of α-syn in this model of experimental synucleinopathy. We focused on microglia next, finding that while microglial burden was significantly upregulated in PFF-seeded, MhcII-deficient mice relative to controls, the microglial activation marker Cd68 was reduced in these mice, suggesting that these microglia were not responsive. Additional analysis of the CNS showed the early appearance of the neurotoxic astrocyte A1 signature and the induction of the Ifnγ-inducible anti-viral response mediated by MhcI in the MhcII-deficient, PFF-seeded mice. Overall, our data suggest that the loss of MhcII function leads to a dysfunctional response in non-classical APCs and that this response could potentially play a role in determining PFF-induced pathology. Collectively, our results identify the critical role of MhcII function in synucleinopathies induced by α-syn prion seeds.

IJMS, Free Full-Text

IJMS, Free Full-Text
IJMS Free Full-Text Research Advances In Mechanical, 52% OFF

IJMS, Free Full-Text

IJMS Free Full Text A High Molecular Mass 26650

IJMS, Free Full-Text
Ijms Free Full Text Neural And Hormonal Basis Of 49680

IJMS Free Full Text Cell Adhesion And Its Endocytic Regulation

IJMS, Free Full-Text
Recomendado para você
-
Laboratório Bronstein CFP Consultoria Empresarial28 março 2025
-
Bronstein popular -_exames_a_preços_populares28 março 2025
-
Bronstein: Agendamento online de exames e vacinas pelo Nav28 março 2025
-
Nir Meir Held in Contempt of Court28 março 2025
-
Emília festas & eventos - Hoje teve açaí e algodão doce para uma28 março 2025
-
Le Mouvement - Pablo Bronstein28 março 2025
-
Vacinas Bronstein28 março 2025
-
Mylene T. Truong MD Anderson Cancer Center28 março 2025
-
Impact of anti-CD20 monoclonal antibodies on serologic response to28 março 2025
-
Amil Saúde - Oficial Planos de Saúde28 março 2025
você pode gostar
-
Kit Topper Topo De Bolo Adulto Chá De Mulheres Personalizado28 março 2025
-
Melhores apps e jogos para iPhone e iPad: 21/01/2016 - TecMundo28 março 2025
-
Image tagged in will you press the button - Imgflip28 março 2025
-
🚨Já tinha visto como é fácil afundar em uma areia movediça? Eu28 março 2025
-
Xadrez - Xadrez Escolar Rondônia - Xadrez Rondônia - Rondônia Xadrez - SESC RO TORNEIO 202328 março 2025
-
Baki season 3, episode 12 recap - the end of the line in Completion28 março 2025
-
Kono Subarashii Sekai ni Bakuen wo! Capitulo 6 Audio Latino Completo - AnimeYT28 março 2025
-
Top 8 Hardest Shiny Pokemon To Hunt In Scarlet and Violet28 março 2025
-
Thanksgiving Day: an American Tradition (texto em inglês com áudio)28 março 2025
-
Let the 'Games' begin28 março 2025