IJMS, Free Full-Text
Por um escritor misterioso
Last updated 16 março 2025

Down syndrome (DS) is the most frequently diagnosed chromosomal disorder of chromosome 21 (HSA21) aneuploidy, characterized by intellectual disability and reduced lifespan. The transcription repressor, Repressor Element-1 Silencing Transcription factor (REST), which acts as an epigenetic regulator, is a crucial regulator of neuronal and glial gene expression. In this study, we identified and investigated the role of REST-target genes in human brain tissues, cerebral organoids, and neural cells in Down syndrome. Gene expression datasets generated from healthy controls and DS samples of human brain tissues, cerebral organoids, NPC, neurons, and astrocytes were retrieved from the Gene Ontology (GEO) and Sequence Read Archive (SRA) databases. Differential expression analysis was performed on all datasets to produce differential expression genes (DEGs) between DS and control groups. REST-targeted DEGs were subjected to functional ontologies, pathways, and network analyses. We found that REST-targeted DEGs in DS were enriched for the JAK–STAT and HIF-1 signaling pathways across multiple distinct brain regions, ages, and neural cell types. We also identified REST-targeted DEGs involved in nervous system development, cell differentiation, fatty acid metabolism and inflammation in the DS brain. Based on the findings, we propose REST as the critical regulator and a promising therapeutic target to modulate homeostatic gene expression in the DS brain.
Ijms Free Full Text Neural And Hormonal Basis Of 49680

IJMS, Free Full-Text

IJMS, Free Full-Text

IJMS, Free Full-Text

IJMS, Free Full-Text

IJMS, Free Full-Text

IJMS Free Full-Text Research Advances In Mechanical, 52% OFF

IJMS, Free Full-Text

non sense codon –

IJMS, Free Full-Text

Fair Priced FavoriteIJMS, Free Full-Text, louis velasquez cgm

IJMS, Free Full-Text
Fair Priced FavoriteIJMS, Free Full-Text, louis velasquez cgm

IJMS, Free Full-Text
Recomendado para você
-
brain test nível 29516 março 2025
-
Lengkap Ada Video, Brain Test Level 295 Siapa Yang Menghabiskan Es Krimku?! ✓16 março 2025
-
3 Icons 1 Word - Mind Puzzle::Appstore for Android16 março 2025
-
how to beat level 295 on brain test|TikTok Search16 março 2025
-
Help Me: Tricky Brain Puzzles - Gameplays: 295 (iOS & Android)16 março 2025
-
Movie Music Games by Tutti Frutti Games16 março 2025
-
Boyfriend Maker APK for Android Download16 março 2025
-
Brain Test Level 295 We need 5 actors - Frenemy16 março 2025
-
Brain Test Game Level 287 to 304 Walkthrough, Brain Test Game Level 287 to 304, Brain Test Level 287, 288, 289, 290, 291, 292, 293, 294, 295, 296, 297, 298, 299, 300, 301, 302, 303, 304 Walkthrough, By Dangamevideos16 março 2025
-
WordQuest! by Tappeal AB16 março 2025
você pode gostar
-
Astral Hub Brookhaven RP Mobile Script16 março 2025
-
Top 6 Hex and Counter Wargames — Meeple Mountain16 março 2025
-
images.ctfassets.net/rporu91m20dc/3WD1mw48ecCKCo0Y16 março 2025
-
Riko-san Bucchigiri desu!16 março 2025
-
Dark Waltz Music - Vampire Masquerade collection16 março 2025
-
IR PRA ESCOLA ATIVIDADES EM CASA - Gerador de Memes Online16 março 2025
-
Shalom Israel (Lago de Galilea) - Album by Various Artists - Apple16 março 2025
-
Joeschmo's Gears and Grounds: Bleach - Thousand-Year Blood War - Episode 7 - Ichigo Points Sword16 março 2025
-
Battle Royale: 5 jogos divertidos - Blog da Lu - Magazine Luiza16 março 2025
-
Review of Naruto Online - MMO & MMORPG Games16 março 2025