Pokémon: The First Movie is the reason Mewtwo is in Detective Pikachu - Polygon

Pokémon: The First Movie: Mewtwo Strikes Back arrived in 1998. More than 20 years later, the story of Ash, Pikachu, Mew, and Mewtwo has new resonance as the Pokémon come to live in live-action while keeping Pokémon game and anime canon alive.

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Pokémon: Detective Pikachu's ending and biggest questions, answered - Polygon

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Detective Pikachu, Pokémon Wiki

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What Pokémon are shiny in Detective Pikachu?