PDF] USE OF SCORE AND CEREBROSPINAL FLUID LACTATE DOSAGE IN DIFFERENTIAL DIAGNOSIS OF BACTERIAL AND ASEPTIC MENINGITIS
Por um escritor misterioso
Last updated 28 março 2025
![PDF] USE OF SCORE AND CEREBROSPINAL FLUID LACTATE DOSAGE IN DIFFERENTIAL DIAGNOSIS OF BACTERIAL AND ASEPTIC MENINGITIS](https://d3i71xaburhd42.cloudfront.net/8f5d57c0faa9363000feb58f702a7c401e619ff5/4-Table2-1.png)
2 point BMS in association with CSF lactate dosage had the same sensitivity and negative predictive value, with increased specificity for diagnosis of bacterial meningitis when compared with 1-point BMS. ABSTRACT Objective: To evaluate Bacterial Meningitis Score (BMS) on its own and in association with Cerebrospinal Fluid (CSF) lactate dosage in order to distinguish bacterial from aseptic meningitis. Methods: Children diagnosed with meningitis at a tertiary hospital between January/2011 and December/2014 were selected. All data were obtained upon admission. BMS was applied and included: CSF Gram staining (2 points); CSF neutrophil count ≥1,000 cells/mm3 (1 point); CSF protein ≥80 mg/dL (1 point); peripheral blood neutrophil count ≥10,000 cells/mm3 (1 point) and seizures upon/before arrival (1 point). Cutoff value for CSF lactate was ≥30 mg/dL. Sensitivity, specificity and negative predictive value of several BMS cutoffs and BMS associated with high CSF lactate were evaluated for prediction of bacterial meningitis. Results: Among 439 eligible patients, 94 did not have all data available to complete the score, and 345 patients were included: 7 in bacterial meningitis group and 338 in aseptic meningitis group. As predictive factors of bacterial meningitis, BMS ≥1 had 100% sensitivity (95%CI 47.3-100), 64.2% specificity (58.8-100) and 100% negative predictive value (97.5-100); BMS ≥2 or BMS ≥1 associated with high CSF lactate also showed 100% sensitivity (47.3-100); but 98.5% specificity (96.6-99.5) and 100% negative predictive value (98.3-100). Conclusions: 2 point BMS in association with CSF lactate dosage had the same sensitivity and negative predictive value, with increased specificity for diagnosis of bacterial meningitis when compared with 1-point BMS.
![PDF] USE OF SCORE AND CEREBROSPINAL FLUID LACTATE DOSAGE IN DIFFERENTIAL DIAGNOSIS OF BACTERIAL AND ASEPTIC MENINGITIS](https://www.journalofinfection.com/cms/asset/4a154c2b-297f-4f0e-8749-6d9970b91ce5/gr1.jpg)
Bacterial meningitis presenting with a normal cerebrospinal fluid
![PDF] USE OF SCORE AND CEREBROSPINAL FLUID LACTATE DOSAGE IN DIFFERENTIAL DIAGNOSIS OF BACTERIAL AND ASEPTIC MENINGITIS](https://d3i71xaburhd42.cloudfront.net/6b1913c12d3e42df4b0d3d04208619550be7a944/2-Table1-1.png)
PDF] Performance of lactate in discriminating bacterial meningitis
![PDF] USE OF SCORE AND CEREBROSPINAL FLUID LACTATE DOSAGE IN DIFFERENTIAL DIAGNOSIS OF BACTERIAL AND ASEPTIC MENINGITIS](https://d3i71xaburhd42.cloudfront.net/2a8388be55f5d8cf676d8a10b94a6468cde22cf4/2-Table1-1.png)
PDF] Aseptic and Bacterial Meningitis: Evaluation, Treatment, and
![PDF] USE OF SCORE AND CEREBROSPINAL FLUID LACTATE DOSAGE IN DIFFERENTIAL DIAGNOSIS OF BACTERIAL AND ASEPTIC MENINGITIS](https://d3i71xaburhd42.cloudfront.net/8f5d57c0faa9363000feb58f702a7c401e619ff5/4-Table2-1.png)
PDF] USE OF SCORE AND CEREBROSPINAL FLUID LACTATE DOSAGE IN
![PDF] USE OF SCORE AND CEREBROSPINAL FLUID LACTATE DOSAGE IN DIFFERENTIAL DIAGNOSIS OF BACTERIAL AND ASEPTIC MENINGITIS](https://d3i71xaburhd42.cloudfront.net/8f5d57c0faa9363000feb58f702a7c401e619ff5/2-Table1-1.png)
PDF] USE OF SCORE AND CEREBROSPINAL FLUID LACTATE DOSAGE IN
![PDF] USE OF SCORE AND CEREBROSPINAL FLUID LACTATE DOSAGE IN DIFFERENTIAL DIAGNOSIS OF BACTERIAL AND ASEPTIC MENINGITIS](https://i1.rgstatic.net/publication/11097526_Development_and_Validation_of_a_Multivariable_Predictive_Model_to_Distinguish_Bacterial_From_Aseptic_Meningitis_in_Children_in_the_Post-Haemophilus_influenzae_Era/links/02e7e518ef43d12fb4000000/largepreview.png)
PDF) Development and Validation of a Multivariable Predictive
![PDF] USE OF SCORE AND CEREBROSPINAL FLUID LACTATE DOSAGE IN DIFFERENTIAL DIAGNOSIS OF BACTERIAL AND ASEPTIC MENINGITIS](https://media.springernature.com/lw685/springer-static/image/art%3A10.1186%2Fs12883-023-03428-8/MediaObjects/12883_2023_3428_Fig1_HTML.png)
The value of elevated cerebrospinal fluid lactate concentrations
![PDF] USE OF SCORE AND CEREBROSPINAL FLUID LACTATE DOSAGE IN DIFFERENTIAL DIAGNOSIS OF BACTERIAL AND ASEPTIC MENINGITIS](https://media.springernature.com/m685/springer-static/image/art%3A10.1186%2Fcc9395/MediaObjects/13054_2010_Article_8862_Fig3_HTML.jpg)
Cerebrospinal fluid lactate concentration to distinguish bacterial
![PDF] USE OF SCORE AND CEREBROSPINAL FLUID LACTATE DOSAGE IN DIFFERENTIAL DIAGNOSIS OF BACTERIAL AND ASEPTIC MENINGITIS](https://d3i71xaburhd42.cloudfront.net/e116cf25e29ff61c464f7e75364a3f5047e21194/3-Table2-1.png)
PDF] Differential diagnosis of acute meningitis. An analysis of
![PDF] USE OF SCORE AND CEREBROSPINAL FLUID LACTATE DOSAGE IN DIFFERENTIAL DIAGNOSIS OF BACTERIAL AND ASEPTIC MENINGITIS](https://media.springernature.com/lw685/springer-static/image/art%3A10.1186%2Fs42466-020-0051-z/MediaObjects/42466_2020_51_Fig1_HTML.png)
S1 guidelines “lumbar puncture and cerebrospinal fluid analysis
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