Genes that Escape Silencing on the Second X Chromosome May Drive Disease

When X-linked genes evade silencing on the “inactive” chromosome in XX cells, some protect women from diseases such as cancer, but others seem to promote conditions such as autoimmunity.

Attrition of X Chromosome Inactivation in Aged Hematopoietic Stem Cells - ScienceDirect

Contiguous erosion of the inactive X in human pluripotency concludes with global DNA hypomethylation - ScienceDirect

Chromosome Xp - an overview

Genes that Escape Silencing on the Second X Chromosome May Drive Disease

The human inactive X chromosome modulates expression of the active X chromosome - ScienceDirect

Skewed X-inactivation is common in the general female population

Escaping but not the inactive X-linked protein complex coding genes may achieve X-chromosome dosage compensation and underlie X chromosome inactivation-related diseases - ScienceDirect

Human genes escaping X-inactivation revealed by single cell expression data, BMC Genomics

Escape from X chromosome inactivation and female bias of autoimmune diseases, Molecular Medicine