Cells, Free Full-Text

Immunometabolism is an emerging discipline in cancer immunotherapy. Tumor tissues are heterogeneous and influenced by metabolic reprogramming of the tumor immune microenvironment (TIME). In the TIME, multiple cell types interact, and the tumor and immune cells compete for limited nutrients, resulting in altered anticancer immunity. Therefore, metabolic reprogramming of individual cell types may influence the outcomes of immunotherapy. Understanding the metabolic competition for access to limited nutrients between tumor cells and immune cells could reveal the breadth and complexity of the TIME and aid in developing novel therapeutic approaches for cancer. In this review, we highlight that, when cells compete for nutrients, the prevailing cell type gains certain advantages over other cell types; for instance, if tumor cells prevail against immune cells for nutrients, the former gains immune resistance. Thus, a strategy is needed to selectively suppress such resistant tumor cells. Although challenging, the concept of cell type-specific metabolic pathway inhibition is a potent new strategy in anticancer immunotherapy.

Label-free, full-field visualization of red blood cell (RBC)

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An illustration of the full-duplex cell-free massive MIMO system.

Amyloid β directly interacts with NLRP3 to initiate inflammasome activation: identification of an intrinsic NLRP3 ligand in a cell-free system, Inflammation and Regeneration

HIV-1 cell-to-cell transmission and broadly neutralizing antibodies, Retrovirology

Cells, Free Full-Text

Cell-Free Synthetic Biology for Pathway Prototyping - ScienceDirect

Cells, Free Full-Text

Cell-free synthetic biology: Engineering in an open world - ScienceDirect