7th Layer, Made in Abyss Wiki

The Final Maelstrom (最果 (さいは) ての渦 (うず) , Saihate no Uzu) is the seventh and last known layer of the Abyss. All that is known for certain about it is that it exists. According to Srajo, there has only been one documented instance of the 7th Layer's Curse. It was found in a sealed letter in the 1st Layer, 250 years ago. As such, the true nature of the Curse of the 7th Layer is unknown. Lyza's notes state that she spotted a figure resembling Reg at the entrance to this layer. She documented it as a

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7th Layer, Made in Abyss Wiki

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My theory on the 7th layer's curse (in the comments) : r/MadeInAbyss